Aldehyde dehydrogenase inhibitors from the mushroom Clitocybe clavipes

Hirokazu Kawagishi; Toshiyuki Miyazawa; Hiroko Kume; Yasushi Arimoto; Takahiro Inakuma

doi:10.1021/np020200j

Aldehyde dehydrogenase inhibitors from the mushroom Clitocybe clavipes

J Nat Prod. 2002 Nov;65(11):1712-4. doi: 10.1021/np020200j.

Authors

Hirokazu Kawagishi¹, Toshiyuki Miyazawa, Hiroko Kume, Yasushi Arimoto, Takahiro Inakuma

Affiliation

¹ Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Shizuoka 422-8529, Japan. achkawa@agr.shizuoka.ac.jp

PMID: 12444711
DOI: 10.1021/np020200j

Abstract

Five fatty acid derivatives including three novel compounds were isolated from the mushroom Clitocybe clavipe. Their structures were elucidated by spectral analyses. These compounds inhibited aldehyde dehydrogenase in vitro.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehyde Dehydrogenase / antagonists & inhibitors*
Basidiomycota / chemistry*
Chromatography, High Pressure Liquid
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification*
Enzyme Inhibitors / pharmacology
Fatty Acids / chemistry
Fatty Acids / isolation & purification*
Fatty Acids / pharmacology
Hydrolysis
Japan
Lipase / metabolism
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Structure-Activity Relationship
Yeasts / enzymology

Substances

Enzyme Inhibitors
Fatty Acids
Aldehyde Dehydrogenase
Lipase